Cardiovascular & heart research studies
Contact usOur research doesn’t skip a beat to improve patient care
We’re changing the way we deliver cardiovascular care. Our team approach to patient and family care provides personalized attention that uses the latest technology and best treatments, but our work doesn’t stop there.
Research plays an important role in our goal to improve heart health and prevent disease. As a national leader in heart and vascular care, surgery and research, we’re finding new ways to prevent, diagnose and treat medical conditions. These medical advances could help people living with heart or vascular conditions live longer and more active lives.
Why you should enroll in a research study
- Study volunteers enrolled in a clinical study receive an extra layer of medical care with frequent follow-up and progress assessments.
- Study volunteers participating in clinical trials may achieve better outcomes than those not enrolled in a study.
- Study volunteers get access to the latest treatments long before they may become widely available.
- As a result of your own experience or that of a loved one, you may want to shape the future of health care for yourself and others.
Find a cardiovascular or heart study
Purpose: The purpose of this study is to test a new device called EMBLOK™. We want to see if it is safe and works well for people having a heart valve replacement. We will compare it to another device called SENTINEL CPS™, which does not protect all the blood vessels to the brain and body.
Research leader: Ravi Ramana, DO
Region: Greater Chicago IL
IRB number: IRB00104408
Purpose: The purpose of this study is to test a new medicine called ziltivekimab for people with heart failure and swelling. Heart failure is when the heart cannot pump enough blood, and swelling can make it worse. We want to see if this medicine can reduce inflammation and improve heart failure symptoms.
Research leader: Owais Malick, MD
Region: Greater Chicago IL
IRB number: IRB00104587
Purpose: The purpose of this study is to test a new balloon that releases medicine to keep blood vessels open and prevent blockages. We want to see if this balloon is safe and works well for adults with narrowed leg arteries.
Research leader: Lewis Schwartz, MD
Region: Greater Chicago IL
IRB number: IRB00104667
Purpose: People with peripheral arterial disease have narrow or blocked blood vessels in their legs, which stops normal blood flow. This study aims to find out how safe and useful a new drug-releasing balloon is for treating this condition, especially in the arteries below the knee. This condition is also called Chronic Limb Threatening Ischemia.
Research leader: Lewis Schwartz, MD
Region: Greater Chicago IL
IRB number: IRB00104668
Purpose: The goal of this study is to find out if a new medicine called ziltivekimab can help people with heart problems and swelling. People in the study will get either ziltivekimab or a fake medicine (placebo) to see how they compare. The study wants to see if ziltivekimab can lower the chances of dying or going to the hospital because of heart problems.
Research leader: Adam Schuldt, MD
Region: Greater Milwaukee WI
IRB number: IRB00104683
Purpose: This study wants to find the best way to treat blood clots in the lungs when the patient’s blood pressure is stable. It compares using blood thinners alone to using blood thinners plus a catheter procedure to remove or dissolve the clot. The goal is to see which treatment helps patients breathe better, have a healthier heart, and exercise more easily over time.
Research leader: Mahesh Raju, MD
Region: Greater Chicago IL
IRB number: IRB00104696
Purpose: This study tests a device called the Carillon Mitral Contour System to help people with heart failure and mitral valve leakage. The device is used to see if it can safely and effectively reduce the leakage. The study is for people with heart failure and mitral valve leakage.
Research leader: Mahesh Raju, MD
Region: Greater Chicago IL
IRB number: IRB00104697
Purpose: This study tests a physical rehabilitation program for people with heart failure. The program aims to improve their physical function and overall health. The study is for patients aged 60 and older who have been admitted to the hospital with heart failure.
Research leader: Nikhil Narang, MD
Region: Greater Chicago IL
IRB number: IRB00104738
Purpose: This study tests an experimental drug called milvexian to see if it can safely reduce the risk of stroke and blood clots in people with atrial fibrillation. The study compares milvexian to another drug called apixaban. It aims to find out if milvexian is safe and effective.
Research leader: Pierre Abi-Mansour, MD
Region: Greater Chicago IL
IRB number: IRB00104742
Purpose: The study wants to see if a drug called Evogliptin can help slow down a heart problem called aortic stenosis. People in the study will take either the drug or a fake pill for two years. They will have different tests and check-ups to see how they are doing. The goal is to find a better way to treat this heart problem.
Research leader: M. Fuad Jan, MD, MBBS, FACC
Region: Greater Milwaukee WI
IRB number: IRB00104761
Purpose: This study tests a new heart valve called the JenaValve Trilogy™ to help people with severe aortic regurgitation. The study aims to see if this valve can safely and effectively replace the faulty valve. It is for patients who are at high risk for open-heart surgery.
Research leader: Ravi Ramana, D.O.
Region: Greater Chicago IL
IRB number: IRB00104785
Purpose: The purpose of this study is to find out if changing a heart valve that is getting narrow can help people before it gets too narrow. There will be two groups in the study: one group will get regular medical care, and the other group will get a new heart valve.
Research leader: Tanvir Bajwa, MD
Region: Greater Milwaukee WI
IRB number: IRB00104804
Purpose: This study tests a new device called the AccuCinch Ventricular Restoration System to help people with heart failure. The study aims to see if this device can safely and effectively improve heart function. It is for patients with heart failure due to a dilated left ventricle.
Research leader: Dominick Bufalino, MD
Region: Greater Chicago IL
IRB number: IRB00104849
Purpose: The purpose of this study is to see if a new treatment called the Symplicity Spyral Renal Denervation system can help people with high blood pressure that is not controlled by medicine. The study will check if the treatment is safe, how well it works, and how long it works.
Research leader: Suhail Allaqaband, MD
Region: Greater Milwaukee WI
IRB number: IRB00104933
Purpose: The purpose of this study is to test the safety and effectiveness of the ALV1 System in patients with heart failure. The study will collect data on heart failure condition before and after the procedure. Participants will be monitored for 60 months.
Research leader: Nasir Sulemanjee, MD
Region: Greater Milwaukee WI
IRB number: IRB00104965
Purpose: The purpose of this study is to see if using a 3D heart map can help doctors put pacemakers in the right place. This new 3D tool might make it easier to see the heart during the procedure. We need volunteers who are getting a pacemaker or defibrillator.
Research leader: Imran Niazi, MD, FACC, FACP
Region: Greater Milwaukee WI
IRB number: IRB00104982
Purpose: This study tests the Impella® device to help people with complex coronary artery disease and reduced heart function during high-risk PCI procedures. The study aims to see if the device can improve heart function and health after the procedure. It is for patients who are at high risk for open-heart surgery.
Research leader: Thomas Levin, MD
Region: Greater Chicago IL
IRB number: IRB00105921
Purpose: The purpose of this study is to see if closing a small hole in the heart can lower the chance of having another stroke. The study uses a device called the GORE® CARDIOFORM Septal Occluder. We are looking for volunteers who have a patent foramen ovale and have had a stroke of unknown origin.
Research leader: Tanvir Bajwa, MD, FACC, FSCAI
Region: Greater Milwaukee WI
IRB number: IRB00105952
Purpose: The purpose of this study is to learn about the safety and usefulness of a new device called the AccuCinch Ventricular Restoration System. We want to compare this device to standard heart failure medications. Participants will either receive the AccuCinch device or continue with their current medical therapy. This study aims to improve heart function and quality of life for patients with heart failure.
Research leader: Abdul Ghani, MD
Region: Greater Chicago IL
IRB number: IRB00105955
Purpose: This study aims to compare two treatments for blood clots in the lungs. Volunteers will receive either a device to remove the clot or medication to dissolve it. The goal is to see which treatment works better.
Research leader: Khawaja Ammar, MD
Region: Greater Milwaukee WI
IRB number: IRB00106410
Purpose: The purpose of this study is to find a new way to fix a leaky heart valve. We will compare a new method called transcatheter mitral valve replacement using a device to the usual surgery for fixing or replacing the heart valve.
Research leader: Tanvir Bajwa, MD
Region: Greater Milwaukee WI
IRB number: IRB00106541
Purpose: The purpose of this study is to test a new device for tricuspid valve replacement. It aims to see if the device works well and is safe for patients with severe tricuspid regurgitation. The study will also evaluate the performance of the device when implanted through the femoral vein.
Research leader: Tanvir Bajwa, MD
Region: Greater Milwaukee WI
IRB number: IRB00107026
Purpose: The purpose of this study is to check the safety and usefulness of a heart device called AccuCinch. It will compare the device to regular heart failure medicines. The study will help understand if the device can improve heart health.
Research leader: Suhail Allaqaband, MD
Region: Greater Milwaukee WI
IRB number: IRB00107124
Purpose: The purpose of this study is to see if the new 3D heart mapping software can help doctors see the heart better during procedures. This will be compared to the standard 2D imaging currently used. The goal is to improve the accuracy and effectiveness of heart treatments.
Research leader: Imran Niazi, MD
Region: Greater Milwaukee WI
IRB number: IRB00107270
Purpose: The purpose of this study is to find out if a new device called the ACURATE Transfemoral Aortic Valve System is safe and helpful. We want to see if it can help patients with a serious heart problem called severe native aortic stenosis who need a procedure called transcatheter aortic valve replacement.
Research leader: Ravi Ramana, DO
Region: Greater Chicago IL
IRB number: IRB00107311
Purpose: Pulmonary hypertension with right heart dysfunction means that the blood pressure in your lungs is high, which makes the right side of your heart work harder. The purpose of this study is to see if a new device called the Aria CV device can help treat patients with this condition.
Research leader: Eric Roberts, MD
Region: Greater Milwaukee WI
IRB number: IRB00107314
Purpose: The purpose of this study is to test if a new medicine, selatogrel, can treat heart attacks. Volunteers will self-administer the medicine using an autoinjector when they feel heart attack symptoms. The study will also test the safety of selatogrel.
Research leader: Muhammad Fuad Jan, MD
Region: Greater Milwaukee WI
IRB number: IRB00107785
Purpose: This study aims to test a new device called the Gradient Denervation System to help people with heart failure and pulmonary hypertension. It will check if the device can improve symptoms like shortness of breath and tiredness. The study will also see if the device is safe to use.
Research leader: Eric Roberts, MD
Region: Greater Milwaukee WI
IRB number: IRB00108668
Purpose: The purpose of this study is to find out if a new device called the Alleviant System is safe and helpful. We want to see if it can help people with a type of heart problem called chronic heart failure. The study will check if the device can make their symptoms better and improve their quality of life.
Research leader: Allan Beall, MD
Region: Greater Chicago IL
IRB number: IRB00110114
Purpose: The purpose of this study is to see if a new device called the Reducer can help people with chest pain that doesn’t get better with regular treatments. The study will check if the device is safe and works well.
Research leader: Joaquin Solis, MD
Region: Greater Milwaukee WI
IRB number: IRB00110792
Purpose: The purpose of this study is to learn more about the study drug milvexian. We want to see if this study drug is safe and helpful in lowering the chances of blood clots, stroke, or another heart attack in people who have recently had a heart attack or chest pain.
Research leader: Joaquin Gonzalez, MD
Region: Greater Chicago IL
IRB number: IRB00110796
Purpose: The purpose of this study is to see if a new drug, ARO-APOC3, can lower high levels of fat in the blood. The study will also check if the drug is safe and if it causes any side effects. Participants will receive the drug or a placebo and will be monitored for changes in their blood fat levels and overall health.
Research leader: Alan Brown, MD
Region: Greater Chicago IL
IRB number: IRB00110849
Purpose: The purpose of this study is to learn about the study drug milvexian. We want to see if this drug is safe and helps prevent blood clots, strokes, or another heart attack in people who recently had a heart attack or chest pain.
Research leader: Mahesh Raju, MD
Region: Greater Chicago IL
IRB number: IRB00111097
Purpose: The purpose of this study is to learn more about the study drug levosimendan. We want to see if this drug can help people with heart failure and lung problems walk farther. We also want to check the drug’s safety.
Research leader: Muhyaldeen Dia, MD
Region: Greater Chicago IL
IRB number: IRB00113631
Purpose: The purpose of this study is to compare two treatments for blood clots in the lungs. One treatment uses blood thinners, and the other uses blood thinners with a special device. The study aims to see which treatment works better to reduce the risk of death and other serious problems.
Research leader: Mahesh N. Raju, MD
Region: Greater Chicago IL
IRB number: IRB00113983
Purpose: The purpose of this study is to find out if a new balloon with medicine is safe and useful to help treat patients with blocked heart arteries. We want to see if this new balloon works better than other treatments for our patients.
Research leader: Suhail Allaqaband, MD
Region: Greater Milwaukee WI
IRB number: IRB00114483
Purpose: This study aims to find better ways to treat high blood pressure in the Chicago community. Volunteers will fill out some health information online, and we will check their blood pressure and other health details from their medical records. The study lasts one year with four online surveys and two in-person visits.
Research leader: Rasha Khatib, PhD, MHS
Region: Greater Chicago IL
IRB number: IRB00115990
Purpose: The purpose of this study is to see if the drug ARO-APOC3 can lower high levels of fat in the blood when given every three months. We will also check if the drug has any side effects and if it is safe to use.
Research leader: Alan Brown, MD
Region: Greater Chicago IL
IRB number: IRB00116083
Purpose: Non-obstructive hypertrophic cardiomyopathy is a condition where the heart’s main pumping chamber becomes thick and stiff, making it hard for the heart to fill with enough blood to pump out. This study aims to learn about a new medicine called aficamten to help treat patients with this heart condition.
Research leader: Patrycja Galazka, MD
Region: Greater Milwaukee WI
IRB number: IRB00117537
Purpose: The purpose of this study is to test a new catheter that takes pictures inside heart arteries. The study will see how well the catheter works and if it gets clear images. Doctors will use the catheter during heart procedures to help treat patients with blocked arteries.
Research leader: Neal Sawlani, MD
Region: Greater Chicago IL
IRB number: IRB00118992